Table 3.
Differentially expressed genes: asthma vs. normal groups
| Gene symbol | Gene name | Biological function | FDa | P-valueb |
|---|---|---|---|---|
| Differentially expressed after RV infection | ||||
| LOXL2 | lysyl oxidase-like 2 | cross-linking of collagen and elastin | 2.2 | 0.010 |
| MMP10 | matrix metallopeptidase 10 (stromelysin 2) | metalloproteinase | 2.2 | 0.040 |
| C15orf48 | chromosome 15 open reading frame 48 | tumor suppressor | 2.2 | 0.008 |
| LOC401074 | hypothetical LOC401074 | NA | 2.1 | 0.004 |
| CCDC58 | coiled-coil domain containing 58 | NA | 2.1 | 0.010 |
| INHBA | inhibin, beta A | growth/differentiation factor | 2.1 | 0.045 |
| IL1F9 | interleukin 1 family, member 9 | cytokine | 2.0 | 0.004 |
| MSMB | microseminoprotein, beta- | tumor suppressor | −3.6 | 0.031 |
| IFI44 | interferon-induced protein 44 | response to virus, cell-cycle arrest | −2.1 | 0.002 |
| Differentially expressed in mock-infected cells | ||||
| ADAM19 | ADAM metallopeptidase domain 19 | metalloproteinase, cell-matrix interactions | 2.8 | 0.023 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | synthesis of ECM, changes in cell shape | 2.6 | 0.034 |
| MAP1Bc | microtubule-associated protein 1B | microtubule assembly | 2.6 | 0.014 |
| LOC401074 | NA | NA | 2.3 | 0.014 |
| 227140_atd | NA | NA | 2.3 | 0.038 |
| FN1 | fibronectin 1 | cell adhesion and migration | 2.3 | 0.050 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | glycosyl hydrolase | 2.3 | 0.002 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | scaffold protein, binds to protein kinase A | 2.3 | 0.040 |
| CCDC58 | coiled-coil domain containing 58 | NA | 2.2 | 0.014 |
| LOXL2 | lysyl oxidase-like 2 | cross-linking of collagen and elastin | 2.2 | 0.006 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | neutrophil activation | 2.2 | 0.046 |
| SCG5 | secretogranin V (7B2 protein) | calcium binding | 2.1 | 0.039 |
| TMSB15 | thymosin beta 15a | metastasis of human prostate and breast cancer | 2.1 | 0.015 |
| COL4A1c | collagen, type IV, alpha 1 | ECM structural protein | 2.1 | 0.022 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | RNA synthesis and metabolism | 2.0 | 0.035 |
| SLC46A3 | solute carrier family 46, member 3 | integral to membrane | 2.0 | 0.031 |
| C15orf48 | chromosome 15 open reading frame 48 | tumor suppressor | 2.0 | 0.019 |
| SERPINE1c | serpin peptidase inhibitor, clade E | plasminogen activator inhibitor | 2.0 | 0.035 |
| INHBA | inhibin, beta A | growth/differentiation factor | 1.9 | 0.028 |
| PPL | periplakin | structural protein, desmosomes | −2.0 | 0.025 |
| MSMBc | microseminoprotein, beta- | tumor suppressor | −2.6 | 0.014 |
ECM, extracellular matrix; FD, fold difference (in expression); NA, not available; RV, rhinovirus.
a
Negative numbers indicate down-regulation in asthmatic cells compared with normal cells.
b
Nominal P-values from unpaired t-test comparison of asthma vs. normal samples (either infected or mock-infected).
c
These genes had more than one probe set that revealed similar expression changes; corresponding fold changes and P-values were averaged.
d
Gene symbol is not available for the probe set.