Table 4.

Functional groupings of genes that are down-regulated after RV infection or differentially expressed in asthma

DAVID functional group term	Gene numbera	Genesb(%)	P-valuec
Down-regulated genes (975 genes)
Biological process (GO database)
post-translational protein modification	120	14%	3×10−8
biopolymer metabolic process	310	35%	5×10−7
intracellular transport	65	7%	2×10−6
ubiquitin cycle	50	6%	1×10−5
protein transport	58	7%	9×10−5
mRNA processing	29	3%	1×10−4
Differentially expressed in asthma compared with normal (42 genes)
Biological process (GO database)
defense response	6	14%	0.008
cell-cell signaling	7	16%	0.003
response to external stimulus	7	16%	0.002
cell surface receptor linked signal transduction	10	23%	0.004
immune response	7	16%	0.003

DAVID, Database for Annotation, Visualization and Integrated Discovery; GO; Gene Ontology; RV, rhinovirus.

^aGenes involved in the term.

^bPercentage of involved genes from total gene list.

^cModified Fisher exact P-value.