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. Author manuscript; available in PMC: 2010 Jun 13.
Published in final edited form as: Science. 2009 Feb 27;323(5918):1211–1215. doi: 10.1126/science.1169096

Figure 3. Spatiotemporal synchrony of astrocytic calcium signaling in APP/PS1 mice.

Figure 3

A) The mean cross-correlogram for all cell pairs (excluding autocorrelations) in transgenic and non- transgenic mice. In APP/PS1 mice there was an increase in the probability that two cells had coordinated activity (n = 3 mice for APP/PS1 and Wt, n = 1,257 cell pairs in transgenic and n = 471 cell pairs in Wt). B) Cell-pair distance (x-axis) versus Correlation coefficient (y-axis). Data were fit to a mono-exponential. In transgenic mice (red), cell-pairs exhibited significantly correlated activity at distances up to 200 µm (p < 0.01, Kruskal-Wallis test with Tukey-Cramer post-hoc) whereas in wildtype mice (blue), cell-pairs were not correlated at inter-cellular distances greater than 50 µm (p = 0.65, Kruskal-Wallis with Tukey-Cramer post-hoc).

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