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The relative error in estimated kinetic parameters after noise has been added to simulated tissue concentration curves. The error in the kinetic parameters was less when the functional model for the AIF was included in the alternating minimization (black), as compared to when no restrictions were placed on the input function (red) and is 10% higher than the error from measurements using a conventionally acquired AIF (blue). The χ2 fits of the estimated input functions are also shown.
