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. Author manuscript; available in PMC: 2010 Jun 14.
Published in final edited form as: J Org Chem. 2005 Jan 21;70(2):631–638. doi: 10.1021/jo0483623

FIGURE 1.

FIGURE 1

Biosynthetic gene cluster of landomycin E (1) in S. globiporus 1912 (lnd). Relevant restriction sites are shown on plasmid pKK3, used in the course of plasmid construction (S, SacI; P, PstI; E, EcoRV). The gene organization of the S. cyanogenus S136 lan cluster in the studied region is essentially the same. So far, only the lndL, lndF, the lndGT functions, and the functions of lndZ4 and lndZ5 were confirmed by knockout and/or complementation experiments, whereas all others have so far been deduced only from in silico analysis.3,6