Table 1.

Allele-specific interactions between Mitf alleles and the Kit^tm1Alf allele visualized by white spotting of the coat

Genotype 1	Inheritance	Genotype 2	Inheritance	Spotting phenotype	Interaction	Reference
Mitf+/+	–	Kit+/+	–	None	–
Mitf+/+	–	Kittm1Alf/+	Sd	Belly spot, white feet and tail	–	Bernex et al., 1996
MitfMi-b/+	Sd	Kit+/+	–	None	–	Steingrimsson et al., 1996
Mitfmi-ew/+	Re	Kit+/+	–	None	–	Nakayama et al., 1998
Mitfmi-rw/+	Re	Kit+/+	–	None	–	Bharti et al., 2008
Mitfmi-vga-9/+	Re	Kit+/+	–	None	–	Hodgkinson et al., 1993
MitfS73A/+	Re	Kit+/+	–	None	–	Bismuth et al., 2008
Mitf mi-bws/+	Re	Kit+/+	–	None		Hallsson et al., 2000
Mitf Mi-b/+	Sd	Kittm1Alf/+	Sd	Belly spot, white feet and tail	NI	This paper
Mitf mi-ew/+	Re	Kittm1Alf/+	Sd	Belly spot, white feet and tail	NI	This paper
Mitf mi-rw/+	Re	Kittm1Alf/+	Sd	Belly spot, white feet and tail	NI	This paper
Mitf mi-vga-9/+	Re	Kittm1Alf/+	Sd	Belly spot, white feet and tail	NI	This paper
MitfS73A/+	Re	Kittm1Alf/+	Sd	Belly spot, white feet and tail	NI	This paper
Mitf mi-bws/+	Re	Kittm1Alf/+	Sd	Extensive spotting around trunk, white feet, white tail	IN	This paper
Ednrbtm1Myks/+	Re	Kit+/+	–	Occasional belly spot	NI	This paper
Ednrbtm1Myks/+	Re	Kittm1Alf/+	Sd	Occasional belly spot	NI	This paper

Mice containing the indicated alleles were obtained by appropriate crosses to yield 14 to 18 doubly heterozygous mice. Note that while many mutant Mitf alleles, when homozygous, cause small eyes (microphthalmia), there were no obvious eye phenotypes in Mitf heterozygotes alone or in combination with Kit^tm1Alf/+.

Backgrounds of parental strains: Mitf +/+; Kit +/+ (C57BL/6), Mitf+/+; Kit^tm1Alf (mixed C57BL/6; C3H/He), Mitf ^Mi-b (C57BL/6J; C3H/RI), Mitf ^mi-ew (C57BL/6Bn), Mitf ^mi-rw (C57BL/6J), Mitf ^mi-vga-9 (mixed C57BL/6J; C3H/He), Mitf^S73A (129S1/Sv; C57BL/6), Mitf ^mi-bws (C57BL/10).

Abbreviations: “–“: not applicable; NI: no gene interaction; IN: gene interaction; Sd: semi-dominant; Re: recessive.