TABLE 7.
IL-10 −819G→A is related to cold susceptibility1
| Type of infection | IL-10 −819G→A | n | Incidence2 | RR (95% CI) | P for RR3 | P overall3 |
| All upper respiratory | G/G | 278 | 0.74 | 1.41 (0.78, 2.55)4 | 0.25 | — |
| A/G | 193 | 0.94 | 1.73 (0.94, 3.14)4 | 0.07 | — | |
| A/A | 29 | 0.5 | 1 | — | 0.08 | |
| Colds | G/G | 278 | 0.63 | 1.90 (0.92, 3.92)4 | 0.08 | — |
| A/G | 193 | 0.79 | 2.24 (1.08, 4.66)4 | 0.03 | — | |
| A/A | 29 | 0.31 | 1 | — | 0.04 |
1
RR, rate ratio.
2
A negative binomial distribution was assumed for regression analysis of infection incidence. Effect was sex independent. Incidence is per person-year.
3
Adjusted for the natural log offset of time in the intervention study, supplementation, smoking, diabetes, dementia, baseline albumin and hemoglobin concentrations, year of enrollment, chronic obstructive pulmonary disease, age, sex, baseline BMI, cardiovascular disease, and hypertension (α = 0.05).
4
Compared with the A/A genotype group.