TABLE 4.

Multiple regression models of maternal and child MTHFR genotypes and Bayley Mental Development Index at 24 mo of age scores¹

	Maternal		Child
Variable	β (95% CI)	P	β (95% CI)	P
MTHFR 6772	−3.52 (−6.12, −0.93)	0.004	−1.73 (−4.31, 0.85)	0.19
Maternal age	−0.23 (−0.62, 0.17)	0.26	−0.22 (−0.62, 0.18)	0.28
Gestational age	0.72 (−0.54, 21.98)	0.26	0.86 (−0.42, 2.13)	0.19
Umbilical cord lead	−0.71 (−1.20, −0.21)	0.005	−0.71 (−1.21, −0.21)	0.006
Maternal IQ	0.12 (0.04, 0.20)	0.002	0.13 (0.05, 0.21)	0.002
Parity	−2.75 (−6.58, 1.08)	0.16	−2.67 (−6.56, 1.23)	0.18
Low folate intake3	1.32 (−3.60, 6.23)	0.53	0.79 (−4.17, 5.75)	0.75
Marital status	4.00 (0.11, 7.88)	0.04	4.27 (0.35, 8.20)	0.03
MTHFR 12984	−2.78 (−7.61, 2.04)	0.26	−0.33 (−4.57, 3.90)	0.88
Maternal age	−0.25 (−0.65, 0.15)	0.22	−0.23 (−0.63, 0.17)	0.25
Gestational age	0.86 (−0.41, 2.14)	0.18	0.86 (−0.43, 2.14)	0.19
Umbilical cord lead	−0.70 (−1.20, −0.20)	0.007	−0.73 (−1.22, −0.23)	0.004
Maternal IQ	0.12 (0.04, 0.20)	0.002	0.13 (0.05, 0.21)	0.002
Parity	−2.84 (−6.72, 1.30)	0.15	−2.94 (−6.83, 0.96)	0.14
Low folate intake3	0.63 (−4.33, 5.59)	0.80	0.68 (−4.30, 5.67)	0.79
Marital status	4.31 (0.38, 8.23)	0.03	4.46 (0.53, 8.39)	0.03

¹IQ, intelligence quotient.

²CC compared with CT compared with TT.

³<520 dietary folate equivalents/d, which is the estimated average requirement for pregnant women.

⁴AA compared with AC/CC.