TABLE 5.
MTHFR haplotype frequencies in relation to Bayley Mental Development Index at 24 mo of age (MDI-24) scores
| Haplotype | Values | Unadjusted MDI-24 scores | Adjusted MDI-24 scores1 |
| Mothers | |||
| 677C-1298A | 27.8 (142)2 | 93.2 ± 1.23 | 93.3 ± 1.2 |
| 677C-1298C | 9.8 (50) | 94.6 ± 2.0 | 93.4 ± 2.1 |
| 677T-1298A | 62.4 (318) | 90.4 ± 0.845 | 89.9 ± 0.84 |
| Children | |||
| 677C-1298A | 26.1 (133) | 92.9 ± 1.3 | 92.6 ± 1.2 |
| 677C-1298C | 11.6 (59) | 91.7 ± 1.8 | 91.4 ± 1.8 |
| 677T-1298A | 62.4 (318) | 91.0 ± 0.8 | 90.5 ± 0.8 |
1
Models adjusted for maternal age, intelligence quotient, low folate intake, gestational age, parity, marital status, and umbilical cord blood lead.
2
Percentage; n in parentheses (all such values).
3
Mean ± SE (all such values).
4
677C-1298A compared with 677T-1298A (P < 0.05).
5
677C-1298 compared with C677T-1298A (P < 0.05).