Table.

Statistical Analysis of Manual Drawing and Automated Drusen Segmentation Results^*

Photo Identification No.	Eye	Manual Drawing, %	Automated, %	False Positives, %	False Negatives, %	Sensitivity	Specificity
1	Right	11.4	13.9	5.7	3.3	0.71	0.59
2a	Left	33.5	29.5	6.5	10.5	0.69	0.78
2b	Right	30.5	31.3	8.7	7.9	0.74	0.84
3	Right	50.8	39.8	6.8	17.30	0.66	0.83
4a	Left	38.0	32.1	10.1	15.7	0.59	0.69
4b	Right	36.5	36.9	11.2	10.5	0.71	0.70
5	Right	17.8	16.4	5.2	6.2	0.65	0.69
6	Left	45.2	37.2	5.3	13.3	0.71	0.86
7	Left	7.2	3.1	0.1	4.2	0.42	0.98
8a	Left	36.6	28.6	5.5	13.4	0.63	0.81
8b	Right	43.0	30.4	2.5	15.2	0.65	0.92
9	Left	43.2	35.1	4.7	12.9	0.70	0.87
10	Left	23.3	29.9	14.1	7.5	0.68	0.53
11	Left	27.6	34.8	1.8	8.9	0.74	0.94
12	Left	48.1	43.2	1.7	6.7	0.86	0.96
13	Right	34.6	34.1	6.5	7.0	0.80	0.81
14	Left	22.3	24.7	6.5	4.1	0.81	0.74
15	Left	41.1	32.3	1.1	9.9	0.76	0.97
16	Right	32.4	36.1	7.0	8.2	0.75	0.78
17	Right	2.5	1.9	0.4	1.1	0.58	0.78

^*Percentages refer to drusen area as a percentage of the 3000-μm-diameter circle. False positives, false negatives, sensitivity, and specificity are calculated on a pixel-by-pixel basis for the automated segmentation compared with the expert manual drawing.