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. Author manuscript; available in PMC: 2011 Apr 22.
Published in final edited form as: J Med Chem. 2010 Apr 22;53(8):3349–3360. doi: 10.1021/jm100052k

Scheme 2. Synthesis of fluorine-substituted derivatives 5a and 5b.

Scheme 2

Reaction conditions and reagents: (a) 2-FCH2CH2OTf (3a) or 3-FCH2CH2CH2OTf (3b), K2CO3, DMF, rt, 16 h, 74%, 84%; (b) Lawesson's reagent, toluene, reflux, 2 h, 78%, 82%.