TABLE I.
SCD | TM | P-value | |
---|---|---|---|
Age | 14.3 ± 6.5 | 14.9 ± 8.8 | 0.73 |
Gender | 15 M, 14 F | 17 M, 24 F | 0.47 |
Chelator | DFO, 23 | DFO, 36 | – |
None, 5 | None, 4 | ||
DFP, 1 | |||
Hemoglobin | 9.3 ± 0.7 | 9.6 ± 0.8 | 0.15 |
Liver iron by biopsy | 16.2 ± 8.6 | 18.1 ± 15.9 | 0.56 |
Total score | 29.3 ± 7.5 | 26.5 ± 8.9 | 0.20 |
Hepatocyte score | 17.1 ± 5.7 | 15.5 ± 6.8 | 0.32 |
Sinusoidal score | 9.1 ± 1.6 | 7.9 ± 2.5 | 0.036 |
Portal score | 3.1 ± 2.0 | 3.1 ± 2.0 | 0.92 |
Fibrosis | 0.6 ± 0.6 | 1.2 ± 0.8 | 0.003* |
Inflammation | 0.7 ± 0.7 | 0.9 ± 0.7 | 0.17 |
Significant at P < 0.05 after Bonferroni correction.
DFO, deferoxamine; DFP, deferiprone.