TABLE 2.
Mouse survival
| BoNT/B antigen | Day postvaccination of blood draw | Mouse survival after administration of the following amt of serum to each animala: |
||||
|---|---|---|---|---|---|---|
| 100 μl | 10 μl | 1 μl | 1:10 dilution | 1:100 dilution | ||
| rHc | 35 | |||||
| 49 | ||||||
| 77 | 1/10 | |||||
| 105 | 10/10 | 10/10 | 10/10 | 0/10 | ||
| Formylated | 35 | 10/10 | 7/10 | 0/10 | ||
| toxoid | 49 | 10/10 | 10/10 | 0/10 | ||
| 77 | 10/10 | 10/10 | 4/10 | 0/10 | ||
| 105 | 10/10 | 10/10 | 0/10 | |||
| Alkylated | 35 | 10/10 | 10/10 | 7/10 | ||
| toxoid | 49 | 10/10 | 10/10 | 10/10 | 0/10 | |
| 77 | 10/10 | 10/10 | 9/10 | 0/10 | ||
| 105 | 10/10 | 10/10 | 9/10 | 0/10 | ||
The indicated amount of serum was administered to each mouse, and the mice were then challenged with 1,000 times the LD50, which is equivalent to 19 ng of toxin complex per mouse. The data represent the number of mice that survived/total number of mice tested.