TABLE 4.
Characteristics of patients with different patterns of HBcAg distribution
| Characteristica | Value for patients (n = 35) who were HBcAg positive in: |
Pb | ||
|---|---|---|---|---|
| Cytoplasm (n = 8) | Nucleus (n = 4) | Mixedc (n = 23) | ||
| Mean age (yr) ± SD | 54.5 ± 7.6 | 55.5 ± 5.2 | 51.7 ± 15.4 | 0.686 |
| Median ALT (U/liter) (range) | 228 (79-852) | 178 (138-569) | 116 (43-1,821) | 0.184 |
| Median AST (U/liter) (range) | 174.5 (39-563) | 118 (56-216) | 87 (25-1,384) | 0.221 |
| Median total bilirubin (mg/dl) (range) | 0.78 (0.4-1.2) | 0.91(0.6-1.3) | 0.82 (0.2-10) | 0.752 |
| Mean PT (INR) ± SD | 1.03 ± 0.09 | 1.03 ± 0.061 | 1.04 ± 0.08 | 0.991 |
| Mean platelets (×103/mm3) ± SD | 168.9 ± 68.7 | 174.8 ± 40.3 | 176.6 ± 39.9 | 0.553 |
| Median AFP (ng/ml) (range) | 6.3 (4-114) | 26 (10-44) | 5.9 (2-36) | 0.055 |
| Mean Ishak fibrosis stage ± SD | 2.13 ± 1.25 | 2.75 ± 2.22 | 2.04 ± 1.22 | 0.875 |
| Mean Ishak necroinflammation grading ± SD | 7.63 ± 3.42 | 7.75 ± 0.96 | 5.65 ± 2.41 | 0.101 |
| Median HBV DNA (log10 cp/ml) (range) | 6.30 (3.36-7.97) | 7.19 (4.79-8.49) | 7.72 (4.99-9.84) | 0.061 |
a
PT, INR, and AFP are as defined for Table 1.
b
The Kruskal-Wallis ANOVA test was used for statistical analysis of the three groups.
c
Mixed nuclear and cytoplasmic localization.