TABLE 2.
Pneumocystis jirovecii DHPS genotypes in respiratory specimens from South African patients
| DHPS genotype | Nucleotide at position (amino acid): |
No. of patients positive/total no. of patients (%) (n = 151) | |
|---|---|---|---|
| 165 (55) | 171 (57) | ||
| Wild type | A (Thr) | C (Pro) | 66/151 (44) |
| Mutant genotype, total | 85/151 (56) | ||
| Single mutation | 36/85 (42) | ||
| Position 165 (M1) | G (Ala) | C (Pro) | 4/85 (5) |
| M1 + wild type | G/A (Ala/Thr) | C (Pro) | 15/85 (18) |
| Position 171 (M2) | A (Thr) | T (Ser) | 7/85 (8) |
| M2 + wild type | A (Thr) | T/C (Ser/Pro) | 10/85 (12) |
| Double mutation | 18/85 (21) | ||
| Positions 165 + 171 (M3) | G (Ala) | T (Ser) | 15/85 (18) |
| M3 + M1 | G (Ala) | T/C (Ser/Pro) | 1/85 (1) |
| M3 + M2 | G/A (Ala/Thr) | T (Ser) | 2/85 (2) |
| Mixed genotypesa | G/A (Ala/Thr) | T/C (Ser/Pro) | 31/85 (36) |
a
Mixed infections in which the presence of mutants with double mutations and the wild type and/or a mixture of mutants with single mutations could not be resolved.