TABLE 7.
Distribution of antibiotic susceptibility according to cyclomodulin genes/Hly and phylogenetic background among 143 E. coli isolates recovered from patients with urosepsisa
| Variable | Quinolones-fluoroquinolonesb |
Amoxicillin |
C3Gc |
Gentamicin |
Cotrimoxazole |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) of isolates |
Pd | No. (%) of isolates |
Pd | No. (%) of isolates |
Pd | No. (%) of isolates |
No. (%) of isolates |
Pd | ||||||
| R (n = 27) | S (n = 119) | R (n = 86) | S (n = 60) | R (n = 7) | S (n = 139) | R (n = 3) | S (n = 143) | R (n = 36) | S (n = 110) | |||||
| Phylogenetic groups | ||||||||||||||
| A | 11 (41) | 16 (13) | (0.002) | 24 (28) | 3 (5) | (<0.001) | 6 (86) | 21 (15) | (<0.001) | 2 (67) | 25 (17) | 9 (25) | 18 (16) | |
| B1 | 2 (7) | 5 (4) | 5 (6) | 2 (3) | 1 (14) | 6 (4) | 1 (33) | 6 (4) | 3 (8) | 4 (4) | ||||
| B2 | 9 (33) | 70 (59) | 0.019 | 32 (37) | 47 (78) | <0.001 | 0 (0) | 79 (57) | 0.003 | 0 (0) | 79 (55) | 13 (36) | 66 (60) | 0.020 |
| D | 5 (19) | 28 (24) | 25 (29) | 8 (13) | (0.028) | 0 (0) | 33 (24) | 0 (0) | 33 (23) | 11 (31) | 22 (20) | |||
| CMs | ||||||||||||||
| pks | 3 (11) | 44 (37) | 0.011 | 18 (21) | 29 (48) | <0.001 | 0 | 47 (34) | 0 | 47 (33) | 2 (6) | 45 (41) | <0.001 | |
| cnf1-Hly | 7 (26) | 28 (24) | 14 (16) | 21 (35) | 0.011 | 2 (29) | 33 (24) | 0 | 35 (24) | 4 (11) | 31 (28) | 0.043 | ||
| Hly alone | 1 (4) | 11 (9) | 8 (9) | 4 (7) | 0 | 12 (9) | 0 | 12 (8) | 2 (6) | 10 (9) | ||||
| cdtB-I | 0 | 3 (3) | 1 (1) | 2 (3) | 0 | 3 (2) | 0 | 3 (2) | 0 | 3 (3) | ||||
| cdtB-IV | 0 | 3 (3) | 1 (1) | 2 (3) | 0 | 3 (2) | 0 | 3 (2) | 0 | 3 (3) | ||||
| cif | 0 | 2 (2) | 1 (1) | 1 (2) | 0 | 2 (1) | 0 | 2 (1) | 0 | 2 (2) | ||||
a
R, resistant; S, susceptible.
b
All resistant isolates were resistant both to quinolone (nalidixic acid) and to fluoroquinolones (either norfloxacin alone or norfloxacin and ciprofloxacin).
c
C3G, extended-spectrum cephalosporins.
d
P values (by Fisher's exact test) are shown where P is <0.05. P values shown in parentheses indicate negative associations between the prevalence of the susceptible strains and the particular trait (phylogenetic group or CM).