TABLE 1.
Univariate logistic regression analysis showing association of vacA and cagA polymorphisms with severity and activity of chronic gastritis in the antrum of 144 Greek adults
| Risk factor | Chronic inflammatory infiltration |
Activity of chronic gastritis |
||||||
|---|---|---|---|---|---|---|---|---|
| No. (%) of isolates with mild/moderate severity | No. (%) of isolates with marked severity | OR (95% CI)a | P | No. (%) of isolates with mild/moderate activity | No. (%) of isolates with marked activity | OR (95% CI)a | P | |
| vacA alleles | ||||||||
| s2 | 25 (17.4) | 17 (11.8) | Reference | 27 (18.8) | 15 (10.4) | Reference | ||
| s1 | 34 (23.6) | 68 (47.2) | 2.941 (1.402-6.171) | 0.004 | 38 (26.4) | 64 (44.4) | 3.032 (1.435-6.405) | 0.004 |
| i2 | 30 (20.8) | 23 (16.0) | Reference | 34 (23.6) | 19 (13.2) | Reference | ||
| i1 | 29 (20.1) | 62 (43.1) | 2.789 (1.385-5.614) | 0.004 | 31 (21.5) | 60 (41.7) | 3.463 (1.704-7.040) | 0.001 |
| cagA EPIYA status | ||||||||
| None | 32 (22.2) | 21 (14.6) | Reference | 33 (22.9) | 20 (13.9) | Reference | ||
| 1 EPIYA-C repeat | 18 (12.5) | 41 (28.5) | 3.471 (1.589-7.58) | 0.002 | 23 (16.0) | 36 (25.0) | 2.583 (1.204-5.539) | 0.015 |
| ≥2 EPIYA-C repeat | 6 (4.2) | 15 (10.4) | 3.810 (1.274-11.389) | 0.017 | 6 (4.2) | 15 (10.4) | 4.125 (1.376-12.363) | 0.011 |
| Mixed infections | 3 (2.1) | 8 (5.6) | 4.063 (0.966-17.091) | 0.056 | 3 (2.1) | 8 (5.6) | 4.4 (1.044-18.542) | 0.044 |
| Vacuolation potential | ||||||||
| None | 32 (22.2) | 24 (16.7) | Reference | 35 (24.3) | 21 (14.6) | Reference | ||
| Low | 12 (8.3) | 22 (15.3) | 2.444 (1.014-5.895) | 0.047 | 11 (7.6) | 23 (16.0) | 3.485 (1.418-8.566) | 0.007 |
| High | 15 (10.4) | 39 (27.1) | 3.467 (1.563-7.690) | 0.002 | 19 (13.2) | 35 (24.3) | 3.070 (1.411-6.681) | 0.005 |
a
Reference, used as the reference category for the calculation of risk in each case.