| Nomenclature | M4 | M5 |
|---|---|---|
| Ensembl ID | ENSG00000180720 | ENSG00000184984 |
| Principal transduction | Gi/o | Gq/11 |
| Antagonists (pKi) | 4-DAMP (8.9), MT3 (8.7), AFDX384 (8.0–8.7), AFDX116 (7–8.7), himbacine (7.9–8.2), tripitramine (7.8–8.2), darifenacin (8.1), pirenzepine (5.9–7.6), guanylpirenzepine (6.5), VU0255035 (5.9), MT7 (<5) | 4-DAMP (9.0), darifenacin (8.6), tripitramine (7.3–7.5), guanylpirenzepine (6.8), pirenzepine (6.2–6.9), himbacine (5.4–6.5), AFDX384 (6.3), AFDX116 (5.3–5.6), VU0255035 (5.6), MT3 (<6), MT7 (<5) |
| Probes (KD) | [3H]NMS (50–100 pM), [3H]QNB (20–80 pM) | [3H]NMS (500–700 pM), [3H]QNB (20–60 pM) |
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