Phosphodiesterases, 3′,5′-cyclic nucleotide (E.C.3.1.4.17)

. 2009 Nov;158(Suppl 1):S228–S230. doi: 10.1111/j.1476-5381.2009.00506_17.x

Nomenclature	PDE1A	PDE1B	PDE1C	PDE2A
Other names	PDE I	PDE I	PDE I	PDE II, cGMP- stimulated cAMP-PDE, CGS-PDE
Ensembl ID	ENSG00000115252	ENSG00000123360	ENSG00000154678	SwissProt O00408
Rank order of affinity	cGMP > cAMP	cGMP > cAMP	cGMP = cAMP	cAMP >> cGMP
Activators	Ca²⁺/CaM	Ca²⁺/CaM	Ca²⁺/CaM	cGMP
Selective inhibitors	SCH51866 (7.2, Vemulapalli et al., 1996), vinpocetine (5.1, Loughney et al., 1996)	SCH51866 (7.2, Vemulapalli et al., 1996)	SCH51866 (7.2, Vemulapalli et al., 1996), vinpocetine (4.3, Loughney et al., 1996)	BAY607550 (8.3–8.8, Boess et al., 2004), EHNA (5.3, Michie et al., 1996)