Nomenclature	NK1	NK2	NK3
Other names	Substance P	Substance K	Neurokinin B, neuromedin K
Ensembl ID	ENSG00000115353	ENSG00000075073	ENSG00000169836
Principal transduction	Gq/11	Gq/11	Gq/11
Rank order of potency	SP > NKA > NKB	NKA > NKB >> SP	NKB > NKA > SP
Selective agonists	SP methylester, [Sar9,Met(O2)11]SP, [Pro9]SP, septide	[β-Ala8]NKA-(4-10),[Lys5,Me-Leu9,Mle10] NKA-(4-10), GR64349	Senktide, [MePhe7]NKB
Selective antagonists	Aprepitant (10.7; Hale et al., 1998), SR140333 (9.5), LY303870 (9.4), CP99994 (9.3), RP67580 (7.6)	GR94800 (9.6), GR159897 (9.5), MEN10627 (9.2), SR48968 (9.0), MEN11420 (8.6; Catalioto et al., 1998)	SR142802 (9.2), SB223412 (9.0; Sarau et al., 1997), PD157672 (7.8)
Probes	[3H]- or [125I]-SP, [3H]- or [125I]-BH-[Sar9,Met(O2)11]SP, [125I]-L703606 (0.3 nM), [18F]-SPA-RQ	[3H]-SR48968 (0.5 nM), [3H]-GR100679, [125I]-NKA	[3H]-Senktide, [125I]-[MePhe7]NKB, [3H]-SR142801 (0.13 nM)