Table 5.
Species (no. tested) | Agent | MIC (μg ml−1) | No. S-DD or I (%) | No. R (%) | ||
---|---|---|---|---|---|---|
Range | IC50 | IC90 | ||||
C. albicans (153) | Amphotericin B | 0.063–1.0 | 0.50 | 1.0 | ||
Flucytosine | ≤0.13– >64 | ≤0.13 | 0.25 | 2 (1.3) | 1 (0.7) | |
Fluconazole | ≤0.13–16 | 0.25 | 0.50 | 1 (0.7) | 0 | |
Itraconazole | ≤0.032–1.0 | ≤0.032 | ≤0.032 | 1 (0.7) | 1 (0.7) | |
Voriconazole | ≤0.032–1.0 | ≤0.032 | ≤0.032 | 0 | 0 | |
Caspofungin | ≤0.032–1.0 | 0.063 | 0.13 | |||
C. glabrata (66) | Amphotericin B | 0.063–2.0 | 0.50 | 1.0 | ||
Flucytosine | ≤0.13– >64 | ≤0.13 | ≤0.13 | 0 | 2 (3.0) | |
Fluconazole | ≤0.13– >64 | 16 | 32 | 36 (54.5) | 4 (6.1) | |
Itraconazole | ≤0.032– >16 | 0.50 | 2.0 | 27 (40.9) | 22 (33.3) | |
Voriconazole | ≤0.032– >8 | 0.50 | 1.0 | 3 (4.5) | 3 (4.5) | |
Caspofungin | ≤0.032–1.0 | 0.25 | 0.50 | |||
C. parapsilosis (35) | Amphotericin B | ≤0.032–2.0 | 0.50 | 1.0 | ||
Flucytosine | ≤0.13–32 | 0.13 | 0.25 | 0 | 2 (5.7) | |
Fluconazole | ≤0.13–2.0 | 0.5 | 1.0 | 0 | 0 | |
Itraconazole | ≤0.032–0.25 | ≤0.032 | 0.13 | 2 | 0 | |
Voriconazole | ≤0.032–0.063 | ≤0.032 | 0.063 | 0 | 0 | |
Caspofungin | ≤0.032–8.0 | 1.0 | 2.0 | |||
Other species* (35) | Amphotericin B | 0.063–2.0 | 0.50 | 1.0 | ||
Flucytosine | ≤0.13–32 | ≤0.13 | 2.0 | 0 | 1 (2.9) | |
Fluconazole | ≤0.13– >64 | 1.0 | 32 | 5 (14.3) | 2 (5.7) | |
Itraconazole | ≤0.032–0.50 | ≤0.032 | 0.25 | 8 (22.9) | 0 | |
Voriconazole | ≤0.032–1.0 | 0.063 | 0.5 | 0 | 0 | |
Caspofungin | ≤0.032–8.0 | 0.25 | 2.0 |
I, Intermediate; R, resistant.
*C. tropicalis (n=6), C. guilliermondii (n=10), C. krusei (n=3), C. lusitaniae (n=6), C. dubliniensis (n=9), Cryptococcus sp. (n=1).