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. 2007 Apr;153(Pt 4):959–967. doi: 10.1099/mic.0.2006/003467-0

Fig. 4.

Fig. 4.

Virulence of CR strains in the mouse colon. (A) The total colon was weighed after the removal of all stools at day 8 post-challenge. Mice infected with DBS255(pCVD438) had colon weights that were not significantly different from those of mice infected with the wt CR. There was no significant difference between the colon weights of mice infected with DBS255 and DBS255(pICC55) and the colon weights of uninfected mice. In contrast, the colon weights of mice infected with strain DBS255(pICC327) were significantly greater than those of uninfected mice (P<0.001) but still slightly less than those of mice infected with the wt (P<0.05). (b) Mice infected with the wt strain and with DBS255(pCVD438) and DBS255(pICC327) all had similarly high pathogen burdens (around 108–109 c.f.u. per colon). In contrast, mice infected with DBS255(pICC55) had significantly lower bacterial loads (around 104–105 c.f.u. per colon; P<0.001), although the levels were still higher than those in mice infected with the DBS255 mutant, from which no challenge bacteria were recovered.