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A DEC2 point mutation was identified in a short sleep family. (A) Pedigree of K7430 family carrying DEC2 mutation (P385R). (B) P385 is localized in the C-terminal proline-rich domain and its flanking sequences are highly conserved among mammalian DEC2 orthologs. (C) Activity recording by wrist actigraphy for one mutation carrier demonstrates the extended active period each day.
