Fig. 3.

In vitro neutralization of MuHV-4 virions by mAbs. MuHV-4 virions (100 p.f.u.) were incubated with mAbs and then plaque-assayed on BHK-21 cells. The highest amounts of each antibody used for neutralization correspond to the amounts given per mouse. Small changes in infectivity (<3-fold reduction) were considered not significant because of the potential for effects such as virion cross-linking to operate in vitro. Thus, only mAbs MG-2C10, T2C12, 230-5B2 and SC-9A5 were considered to be neutralizing. Consistent results were obtained in at least two experiments for each mAb.