Figure 6. Tetramer staining of T-cell clones isolated from haemophilic subject IV-3.
A. T-cell clones #15, 19, 11, and 12 were stimulated with HLA-mismatched PBMCs and PHA. Thirteen days later, the clones were incubated with PE-labeled DR1104 tetramers loaded with peptide FVIII2202-2221 and APC-labeled anti-human CD4 IgG. B. Two of the clones were incubated with DR1104 tetramers loaded with an irrelevant peptide (FVIII2186-2205) as a negative control.