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Pyrazole potentiation of TNFα hepatotoxicity is blunted in CYP2E1 knockout mice as compared to SV129 wild type mice. TNFα alone toxicity is low and similar in the wild type and CYP2E1 null mice, whereas TNFα plus pyrazole toxicity is elevated in wild type but not in CYP2E1 knockout mice (note log scale for ALT/AST levels)
