TABLE 3.

Sequence comparison of the CDRs

The VHH are grouped into the three different neutralization categories, and the amino acid sequences of their CDRs are aligned and compared. The consensus sequence with Chothia numbering to denote the CDR position (52) is shown in the top row. Residues that are identical to the consensus sequence are shown in dashes. Variants of the YYD¹⁰² motif at the end of the CDR3 are shown in boldface type, and the YYD¹⁰² motif is underlined. The symbols *, †, and ‡ are used to denote groups of VHH with similar CDR sequences but with variations only in the YYD¹⁰² motif. (*, Y101N substitution; ‡, Y101N and D102Y mutations; †, Y101N and/or D102Y mutations.)