FIGURE 4.

PGC-1α and mitochondrial content decrease in TA muscle 10 days after denervation. A, weight of the TA decreased 10 days after cutting the sciatic nerve (denervated). *, p < 0.001, n = 6. B, PGC-1α and mitochondrial proteins were decreased in denervated TA. Protein levels were quantified by Western blot. Equal amounts of total protein were loaded per lane. *, p < 0.05. C, the activity of the mitochondrial enzymes, citrate synthase and succinate dehydrogenase, decreased in the denervated TA. *, p < 0.001.