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. 2010 Apr 2;285(25):19561–19571. doi: 10.1074/jbc.M109.092916

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FIGURE 5. — Effect of reduced PA Glc-6-PD expression on HPV. A, representative Western blot showing knockdown of Glc-6-PD (G6PD) expression by siRNA targeting Glc-6-PD but not by scrambled (NT) siRNA. Expression of α-actin, a cytoskeletal protein, was unaffected by Glc-6-PD siRNA. B, traces showing a typical response to hypoxia by PA transfected with NT (blue line) and Glc-6-PD (yellow line) siRNA. ReO, reoxygenation; WO, washout. C, group data showing the effects of NT and Glc-6-PD siRNA on HPV (n = 10). *, p < 0.05. D, Glc-6-PD activity was significantly lower in lungs from Glc-6-PD^mut(−/−) mice than Glc-6-PD^mut(+/−) or Glc-6-PD^mut(+/+) mice (n = 6). E, hypoxia-induced PA contraction was significantly weaker in Glc-6-PD^mut(−/−) than Glc-6-PD^mut(+/−) mice (n = 6).