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. 2010 Apr 14;30(15):5404–5414. doi: 10.1523/JNEUROSCI.4893-09.2010

Figure 4.

Figure 4.

P17 to P20 NP1/2 KO animals strengthen AMPAR-mediated currents by an NP1/2-independent mechanism and develop aberrantly large current amplitudes. A, Example traces at +40 mV and −70 mV from WT and NP1/2 KO neurons at age P19 showing maximal evoked responses (50 μA stimulus). B, Average saturating AMPAR and NMDAR-mediated responses. C, Example traces of presumed single fiber responses from a WT neuron (10 μA stimulus) and a KO neuron (7.5 μA stimulus) recorded at +40 mV and −70 mV. D, Average minimal AMPAR and NMDAR-mediated responses. B, D, Data displayed as mean ± SEM. For WTs n = 8 animals and 17 cells. For KOs n = 9 animals and 17 cells. *p < 0.05. E, Examples of PPRs at −70 mV in cyclothiazide. F, Quantification of PPRs recorded at −70 mV and +40 mV. For −70 mV recordings n = 3 WT animals (8 cells) and n = 2 KO animals and 6 cells. For +40 mV recordings n = 2 animals and 4 cells for both genotypes. Data displayed as mean ± SEM.