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. 2010 May 1;128(1):89–101. doi: 10.1007/s00439-010-0828-1

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© The Author(s) 2010

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Fig. 1 — Simulation results: 20–500 risk alleles and OR = 1.1–1.5, for area under the ROC curve (AUC), case concentration (CCNT) and genetic risk standard deviation (SD). #Horizontal reference line indicates threshold of 80% of CRC cases being captured in top 50% of ranked test scores. *Horizontal reference line indicates theoretical maximum standard deviation of the genetic risk distribution (SD) explained by heritable factors (SD = 1.2)