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. 2010 May 20;10:54. doi: 10.1186/1471-213X-10-54

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Copyright ©2010 Stevens et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ablim1 lateral plate asymmetry is maintained in the absence of Nodal. Expression, as assessed by WISH with the 3'UTRa probe. In iv/iv mutants (a-c), (a) left-sided, (b) bilateral and (c) right sided expression was detected. (d) Left-sided Ablim1 expression in a Nodal^D600/D600(D600/D600) embryo. (e) Normal, left-sided expression of Ablim1 in a Pitx2c^-/-embryo. Nodal^Δnode/-(node/-) embryos show either loss of asymmetric Ablim1 expression (f) or left-sided Ablim1 expression (g). The posterior most extent of LPM expression is indicated by a closed arrowhead.