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. Author manuscript; available in PMC: 2010 Jun 14.
Published in final edited form as: Nature. 2009 Aug 19;461(7260):99–103. doi: 10.1038/nature08242

Figure 3. Correlation of Rho GTPase activation and cell edge velocity as a function of time and space.

Figure 3

(a-c) Cross-correlation functions between edge velocity and GTPase activation at D = 0 (red line), 0.6, 1.3, 2.5, 4.4 and 6.3 μm. Dashed line: 95% confidence level for correlation values. (d-f) Blue line: magnitude of cross-correlation maximum as a function of D (blue bracket in b). Red line: time lag of cross-correlation maxima as a function of D (red bracket in b). Dashed lines: 95% confidence interval estimated by bootstrap sampling of residual distributions to the spline fits (see Supplementary Methods). Grey area: region with correlation values below 95% confidence. Of note, time lags of cross-correlation maxima in this area are no longer meaningful. Data derived from n = 6 (Rac1), n=5 (Cdc42) and n = 5 (RhoA) cells.