Skip to main content
. Author manuscript; available in PMC: 2010 Jun 14.
Published in final edited form as: Biochem J. 2009 Sep 25;423(2):179–187. doi: 10.1042/BJ20090870

Figure 1. The CHD4 PHD2 finger binds histone H3.

Figure 1

(a) The NuRD complex and its major components. The nucleosomes are shown as blue cylinders. (b) Architecture of CHD4: the N-terminal tandem of PHD fingers, the two adjacent chromodomains and a catalytic ATPase module. (c) Binding of the GST-fusion CHD4 PHD2 finger to biotinylated histone peptides. (d) Superimposed 1H,15N HSQC spectra of 0.2 mM PHD2, collected during titrating in the indicated histone peptides. The spectra are colour-coded according to the protein/peptide ratio, the position of low intensity peaks of E447 are marked by an asterisk.