Table 1.

PTK6 substrates and binding partners.

Protein	Association	Substrate target	Proposed function/role	Reference
ADAM-15A and E	Yes	N/D	Not validated	[41]
AKT	Yes	Yes	Growth regulation	[29], Zheng and Tyner, unpub.
beta-catenin	Yes	Y64, Y331/333, Y142	Growth regulation	[30]
beta-tubulin	No	Yes	Not validated	[31]
ErbB1	Yes	N/D	Growth regulation	[42]
ErbB2	Yes	N/D	Growth regulation	[35,43]
ErbB3	Yes	N/D	Growth regulation	[35,46]
ErbB4	Yes	N/D	Not validated	[35]
FLJ39441	No	Yes	Not validated	[31]
GapA (p65)	PTK6 SH2	Not likely	Differentiation	[27]
GNAS	No	Yes	Not validated	[31]
IRS-4	PTK6 SH2 and SH3	N/D	Growth and migration	[23]
KAP3A	Yes	C-terminal tyrosines	Migration	[31]
MAPK	Yes	N/D	Not validated	[35]
p190RhoGAP	Yes	Y1105	Growth and migration	[32]
Paxilin	Yes	Y31, Y118	Migration and invasion	[23]
PSF	PTK6 SH3	C-terminal tyrosines	Growth regulation	[24]
PTEN	YES	N/D	Not validated	[35]
PTK6	Intramolecular	Y13, Y61, Y66, Y114, Y342, Y351	Regulation of kinase activity	[2,16,17,19,20]
Sam68	PTK6 SH2 and SH3	Y435; Y440; Y443	Inhibition of Sam68	[18,22,33–35]
SLM1; SLM2	N/D	Yes	Inhibition of SLM1 and SLM2	[36]
STAP2	STAP2 SH2	Y250	STAT3 activation	[28,37]
STAT3	N/D	Yes	Growth regulation	[38]
STAT5b	N/D	Y699	Growth regulation	[39]
23 kDa protein	Yes	N/D	Protein not identified	[56]
100 kDa protein	(STAP2-mediated)	Likely	Protein not identified	[28]

NLS = Nuclear localization signal; SH = Src-homology domain; N/D = Not determined.