Table 3.
Intracellular localization of PTK6 in normal tissues and cancer cells.
| Group | Tissue/cell | Sub-category | Localization (method) | Reference |
|---|---|---|---|---|
| Breast | Breast cancer | N/D | [2,69,83] | |
| Grade I; Grade III | C; PN (IHC) | [93] | ||
| Grade II; low-mod. PTK6 | C+N (IHC; IF) | [34,47,85] | ||
| Grade III; high PTK6 | C+N; N (IHC) | [47,93,106] | ||
| Low PTK6; T47D | C (IHC; IF) | [56,106] | ||
| Grade III; high PTK6 | C+N; C (IHC) | [85] | ||
| MCF7 cells | C+SNB (IF) | [18] | ||
| G.I. tract | Esophagus | N/D | [12] | |
| Stomach | N/D | [12] | ||
| Small intestine | N/D | [3,13,57] | ||
| villus; crypt 72 h after irr. | C+N; isolated N (IHC) | [59,68] | ||
| crypt 6 h after irradiation | C+N (IHC) | [68] | ||
| Colon mucosa | N/D | [3,13,57,72] | ||
| C; C+N (IHC) | [12] | |||
| Colon cancer; HT29 cells | C; C+N; C+SNB (IHC; IF) | [12,18] | ||
| Head and neck | Normal oral epithelium | high PTK6 | C; C+N; N (IHC) | [62] |
| Oral SCC; OSCC25 cells | moderate PTK6 | C+N; N (IHC) | [62] | |
| OSCC3 cells | low PTK6 | C; PN (IF; Frac) | [62] | |
| Laryngeal cancer | N; C+N (IHC) | [73] | ||
| Lymphocytes | T-cells | N/D | [63] | |
| T and B-cell lymphomas | N (Frac) | [63] | ||
| Ovary | Ovarian cancer | C; C+N; C+N (IHC) | [71] | |
| Prostate | Normal | N/D | [13] | |
| prostate | N (IHC) | [60] | ||
| Prostatic | BPH | C+N (IHC) | [60] | |
| disease | PIN | C+PN (IHC) | [60] | |
| Prostate cancer | Gleason 2 | C+N (IHC) | [60] | |
| Gleason 3 | C+N (IHC) | [60] | ||
| Gleason 3–4; LNCaP cells | C+PN+SNB+N (IHC; IF) | [60] | ||
| Gleason 4; PC3 cells | C (IHC; IF) | [60] | ||
| Epidermis | Skin | N/D | [1,57] | |
| epithelium | C; C+N (IHC) | [61] | ||
| SCC | C; C+N (IHC) | [61] | ||
| HaCaT cells | Low density; low PTK6 | C+N (IF) | [61] | |
| High density; high PTK6 | C+N (IF) | [61] | ||
| Epid. cancer (A431 cells) | High density | C+N (IF) | [84] | |
| 2 h scratch; +EGF | C+N+MR (IF) | [84] | ||
| 6 h scratch | C+N (IF) | [84] |
SCC = Squamous cell carcinoma; BPH = Benign prostatic hyperplasia; PIN = Preneoplatic intraepithelial neoplasia; C = Cytoplasm; N = Nucleus; PN = Perinuclear; SNB = SAM68 nuclear bodies; MR = Membrane ruffles; IHC = Immunohistochemistry; IF = Immunofluorescence; Frac = Fractionation; N/D = Not determined; Epid. = Epidermoid. Predominant localization is in bold.