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. Author manuscript; available in PMC: 2011 Jun 30.
Published in final edited form as: Respir Physiol Neurobiol. 2010 May 12;172(1-2):63–71. doi: 10.1016/j.resp.2010.05.006

Figure 1.

Figure 1

A. Brief hypoxia significantly suppresses soluble immunoreactive TNF-α secretion induced by E. coli serotype O55:B5 LPS (100 ng/mL) into supernatants of NR8383 rat alveolar macrophages. B. Time course of IL-1β production in E. coli LPS-stimulated cell lysates assayed by IL-1β-specific ELISA for total protein at time points shown after adding 100 ng LPS/mL. Values in both panels are means ± SD of quadruplicate determinations from at least three experiments per time point. Supernatants contained only trace amounts of IL-1β protein, while cell lysates contained only trace amounts of immunoreactive TNF-α protein. Open squares, LPS + hypoxia or LPS + combined hypoxia/reoxygenation (H/R) time-matched values. Filled squares, normoxic LPS control values; * P < 0.01 vs. time-matched normoxic LPS control value.