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. 2008 Jun 1;63(11):1022–1029. doi: 10.1016/j.biopsych.2007.12.007

Figure 6.

Figure 6

IL-6 response to typhoid vaccine predicts enhanced neural activation within left substantia nigra during Stroop task performance. (A) fMRI analysis revealed heightened BOLD activity within left substantia nigra during performance of the cognitive Stroop task in the vaccine condition (threshold p < .001, illustrated at p < .005 uncorrected). (B) Scatter plot illustrating the relationship between substantia nigra activity (BOLD response within an 8 mm region of interest centered on the peak voxel at MNI −12, −2, −8) and mean IL-6 response to typhoid vaccine (p = .005). BOLD, blood oxygenation level-dependent; fMRI, functional magnetic resonance imaging; IL-6, interleukin-6; MNI, Montreal Neurological Institute.