Table 1.
Target protein | Phospho-Site | Protein Class/Function of Phospho-Site | Kinase | Brain Region |
---|---|---|---|---|
GluR1 | S845 | AMPA receptor/positive modulator | PKA | STR/HPC |
S831 | AMPA receptor/positive modulator | PKC/CaMKII | STR/HPC | |
NR1 | S897 | NMDA receptor/positive modulator | PKA | STR/HPC |
TH | S40 | Dopamine Synthesis/Essential for enzyme activity | PKA | STR |
CREB | S133 | Gene Transcription/Activator | PKA | STR/HPC |
ERK1/2 | T183 | Protein Kinase/Activator | MEK | STR/HPC |
DARPP-32 | T34 | Protein Phosphatase Inhibitor/Activation | PKA/PKG | STR |
T75 | Protein Kinase Inhibitor/Activator | Cdk5 | STR | |
S97 | ModulatesT34 Phosphorylation | CK2 | STR | |
S130 | ModulatesT34 Phosphorylation;Modulates nuclear transport | CK1 | STR | |
Spinophilin | S94 | Cytoskeletal Protein/Anchoring Protein | PKA | STR/HPC |
Synapsin | S549 | Synaptic vehicle protein/Modulates cytoskeleton interactions | Cdk5 | STR/HPC |
S603 | Synaptic vesicle protein/ Modulates vesicle trafficking | CaMKII | STR/HPC | |
GSK3β | S9 | Protein Kinase/Inhibits enzyme activity | Akt | STR/HPC |
Akt | S473 | Protein Kinase/Promotes kinase activity | PKB | STR/HPC |
T308 | Protein Kinase/Promotes kinase activity | PKB | STR/HPC |
Abbreviations: CaMKII, Ca2+/calmodulin-dependent protein kinase II; Cdk5, cyclin-dependent protein kinase 5; CK1, casein kinase 1; CK2, casein kinase 2; CREB, cAMP response element binding protein; DARPP-32, dopamine- and cAMP-regulated phosphoprotein, Mr=32 kDa; MEK, MAP/ERK kinase; NMDA, N-methyl-D-aspartate; AMPA, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid; PKA, cAMP-dependent protein kinase; PKC, protein kinase C; PP1, protein phosphatase 1; STR, striatum; HPC, hippocampus.