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. Author manuscript; available in PMC: 2011 Jun 25.
Published in final edited form as: Brain Res. 2010 Apr 25;1342C:11–23. doi: 10.1016/j.brainres.2010.04.034

Table 1.

Sites of phosphorylation monitored in brain after DFP treatment using CNSProfile.

Target protein Phospho-Site Protein Class/Function of Phospho-Site Kinase Brain Region
GluR1 S845 AMPA receptor/positive modulator PKA STR/HPC
S831 AMPA receptor/positive modulator PKC/CaMKII STR/HPC
NR1 S897 NMDA receptor/positive modulator PKA STR/HPC
TH S40 Dopamine Synthesis/Essential for enzyme activity PKA STR
CREB S133 Gene Transcription/Activator PKA STR/HPC
ERK1/2 T183 Protein Kinase/Activator MEK STR/HPC
DARPP-32 T34 Protein Phosphatase Inhibitor/Activation PKA/PKG STR
T75 Protein Kinase Inhibitor/Activator Cdk5 STR
S97 ModulatesT34 Phosphorylation CK2 STR
S130 ModulatesT34 Phosphorylation;Modulates nuclear transport CK1 STR
Spinophilin S94 Cytoskeletal Protein/Anchoring Protein PKA STR/HPC
Synapsin S549 Synaptic vehicle protein/Modulates cytoskeleton interactions Cdk5 STR/HPC
S603 Synaptic vesicle protein/ Modulates vesicle trafficking CaMKII STR/HPC
GSK3β S9 Protein Kinase/Inhibits enzyme activity Akt STR/HPC
Akt S473 Protein Kinase/Promotes kinase activity PKB STR/HPC
T308 Protein Kinase/Promotes kinase activity PKB STR/HPC

Abbreviations: CaMKII, Ca2+/calmodulin-dependent protein kinase II; Cdk5, cyclin-dependent protein kinase 5; CK1, casein kinase 1; CK2, casein kinase 2; CREB, cAMP response element binding protein; DARPP-32, dopamine- and cAMP-regulated phosphoprotein, Mr=32 kDa; MEK, MAP/ERK kinase; NMDA, N-methyl-D-aspartate; AMPA, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid; PKA, cAMP-dependent protein kinase; PKC, protein kinase C; PP1, protein phosphatase 1; STR, striatum; HPC, hippocampus.