Table 3.
Treatment | Racine Score | Racine Score | N | Mortality |
---|---|---|---|---|
15 min | 2h | |||
Mean ±SEM | Mean ± SEM | |||
Vehicle | 1 | 1 | 5 | 0/5 |
DFP (4 mg/kg) | 2.6 ± 0.42* | 3.0 ± 0.50* | 7 | 3/7 |
DFP (4mg/kg)+PCH|| (25mg/kg) | 1.3 ± 0.18§§ | 1.1 ± 0.14§ | 7 | 0/7 |
DFP (4mg/kg)+Varenicline (25 mg/kg)# | 2.4 ± 0.64** | 3.3 ± 0.28** | 7 | 0/7 |
DFP (4 mg/kg) + AC-260584 (25 mg/kg)† | 1.2 ± 0.14§§ | 2.6 ± 0.48* | 7 | 0/7 |
Ki=46.49nM at muscarinic cholinergic receptors; Wang et al., (2005) Acta Pharmacologica Sinica, 26,527.
Ki=0.06nM (α4β2); 322nM (α7); J. Med Chem (2005) 38, 3774.
Ki=32 nM (muscarinic); Behavioral Neuroscience (2008), 122, 570.
p<.05 vs Vehicle;
p<.01 vs Vehicle;
p<.05 vs DFP alone,
p<.01 vs DFP alone, ANOVA with Newman-Keuls post-test.