Table 3.

Effect of pretreatment with muscarinic and nicotinic cholinergic ligands on Racine Seizure Score and mortality after treatment of FVB mice with DFP.

Treatment	Racine Score	Racine Score	N	Mortality
	15 min	2h
	Mean ±SEM	Mean ± SEM
Vehicle	1	1	5	0/5
DFP (4 mg/kg)	2.6 ± 0.42*	3.0 ± 0.50*	7	3/7
DFP (4mg/kg)+PCH|| (25mg/kg)	1.3 ± 0.18§§	1.1 ± 0.14§	7	0/7
DFP (4mg/kg)+Varenicline (25 mg/kg)#	2.4 ± 0.64**	3.3 ± 0.28**	7	0/7
DFP (4 mg/kg) + AC-260584 (25 mg/kg)†	1.2 ± 0.14§§	2.6 ± 0.48*	7	0/7

^||K_i=46.49nM at muscarinic cholinergic receptors; Wang et al., (2005) Acta Pharmacologica Sinica, 26,527.

^#K_i=0.06nM (α4β2); 322nM (α7); J. Med Chem (2005) 38, 3774.

^†K_i=32 nM (muscarinic); Behavioral Neuroscience (2008), 122, 570.

^*p<.05 vs Vehicle;

^**p<.01 vs Vehicle;

^§p<.05 vs DFP alone,

^§§p<.01 vs DFP alone, ANOVA with Newman-Keuls post-test.