Table 5.
Drug Treatment | STRIATUM | N | p value | HIPPOCAMPUS | N | p value | ||
---|---|---|---|---|---|---|---|---|
Veh | Drug(s) | Veh | Drug(s) | |||||
DFP (4 mg/kg I.P.) | 100 ± 13 | 252 ± 46 | 5 | p<.01 | 100 ± 15 | 162 ± 20 | 5 | p<.01 |
Donepezil (5 mg/kg I.P.) | 100 ± 6.0 | 149 ± 7.8 | 6 | p=0.0005 | 100 ± 6.1 | 113 ± 4.3 | 6 | p=0.02 |
Oxotremorine (1 mg/kg SC) | 100 ± 9.0 | 150 ± 17 | 6 | p=0.02 | 100 ± 8.6 | 170 ± 14 | 5 | p=0.006 |
DFP (4 mg/kg) + PCH (25mg/kg) | 100 ± 13 | 104 ± 14 | 5 | NS | 100 ± 17 | 94 ± 6.0 | 5 | NS |
DFP (4 mg/kg) + AC-260584 (25 mg/kg) | 100 ± 17 | 314 ± 73 | 5 | p<.05 | 100 ± 11 | 185 ± 31 | 5 | p<.05 |