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. Author manuscript; available in PMC: 2011 Jun 25.
Published in final edited form as: Brain Res. 2010 Apr 25;1342C:11–23. doi: 10.1016/j.brainres.2010.04.034

Table 5.

Comparison of the effects of DFP, the acetylcholinesterase inhibitor, Donepezil, and the non-selective muscarinic receptor agonist, Oxotremorine, on the phosphorylation state of synapsin at S549 measured 2h (DFP) or 1h (Donepezil and after drug treatment.

Drug Treatment STRIATUM N p value HIPPOCAMPUS N p value
Veh Drug(s) Veh Drug(s)
DFP (4 mg/kg I.P.) 100 ± 13 252 ± 46 5 p<.01 100 ± 15 162 ± 20 5 p<.01
Donepezil (5 mg/kg I.P.) 100 ± 6.0 149 ± 7.8 6 p=0.0005 100 ± 6.1 113 ± 4.3 6 p=0.02
Oxotremorine (1 mg/kg SC) 100 ± 9.0 150 ± 17 6 p=0.02 100 ± 8.6 170 ± 14 5 p=0.006
DFP (4 mg/kg) + PCH (25mg/kg) 100 ± 13 104 ± 14 5 NS 100 ± 17 94 ± 6.0 5 NS
DFP (4 mg/kg) + AC-260584 (25 mg/kg) 100 ± 17 314 ± 73 5 p<.05 100 ± 11 185 ± 31 5 p<.05