Table 1.

Characteristics of the study population. Data are given for all children and for groups defined by NRG1 genotype CC/CT vs. TT, and the presence or absence of PVL, CP and DD >= 12 months. If not indicated otherwise, numbers are column percents. Variables tested as potential confounding factors are marked in grey.

	All children	SNP8NRG221533 genotype			Cystic Periventricular Leukomalacia			Cerebral Palsy			Developmental Delay ≥ 12 months
	N=54	CC, CT N=42	TT N=12	OR (CI 95%)	Yes N=10	No N=44	OR (CI 95%)	Yes N=5	No N=49	OR (CI 95%)	Yes N=9	No N=45	OR (CI 95%)
	%	%	%		%	%		%	%		%	%
NRG1 CC/CT		-	-	-	70	80	0.6 (0.1-2.8)	40	82	0.2 (0.02-1.0)	56	82	0.3 (0.1-1.2)
Gestation < 30 wks	63	62	67	0.8 (0.2-3.1)	90	57	6.8 (0.8-59)	80	61	2.5 (0.3-24)	89	58	5.9 (0.7-51)
Birth weight < 1000g	44	48	33	1.8 (0.5-7.0)	70	39	3.7 (0.8-16)	80	41	5.8 (0.6-56)	67	40	3.0 (0.7-14)
Small for gestational age	22	24	17	1.6 (0.3-8.4)	20	23	0.9 (0.2-4.7)	40	20	2.6 (0.4-18)	33	20	2.0 (0.4-9.6)
Male	50	45	67	0.4 (0.1-1.6)	60	48	1.6 (0.4-6.6)	60	49	1.6 (0.2-10)	67	47	2.3 (0.5-10)
Mother German	72	69	83	0.5 (0.1-2.3)	60	75	0.5 (0.1-2.1)	100	69	-	78	71	1.4 (0.3-7.8)
Multiple pregnancy	17	14	25	0.5 (0.1-2.4)	10	18	0.5 (0.1-4.5)	20	16	1.3 (0.1-13)	11	18	0.6 (0.1-5.3)
Prenatal glucocorticoid, complete	81	76	100	-	70	84	0.4 (0.1-2.1)	80	82	0.9 (0.1-9.1)	78	82	0.8 (0.1-4.3)
Pregnancy induced hypertension	19	19	17	1.2 (0.2-6.5)	20	18	1.1 (0.2-6.3)	20	18	1.1 (0.1-11)	11	20	0.5 (0.1-4.5)
Preterm labor	65	60	83	0.3 (0.1-1.5)	80	61	2.5 (0.5-13)	80	63	2.3 (0.2-22)	89	60	5.3 (0.6-46)
Rupture of membranes >12hrs	22	24	17	1.6 (0.3-8.4)	30	20	1.7 (0.4-7.8)	20	22	0.9 (0.1-8.5)	22	22	1.0 (0.2-5.6)
Chorioamnionitis	30	29	33	0.8 (0.2-3.2)	60	23	5.1 (1.2-22)	20	31	0.6 (0.1-5.5)	44	27	2.2 (0.5-9.6)