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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2010 Mar 4;49(2):210–220. doi: 10.1016/j.yjmcc.2010.02.021

Figure 4. Effect of AMPK inhibition on cardiac remodeling in WT and APN-KO mice subjected to TAC.

Figure 4

A and B, The ratio of heart weight to body weight (HW/BW)(A) and lung weight to body weight (LW/BW) in WT and KO mice in the presence of compound C or vehicle at 3 weeks after TAC. C and D, Echocardiographic analysis of the fractional shortening (FS)(C) and LV end systolic diameter (LVEDD)(D) for WT and KO mice treated with compound C or vehicle at 3 weeks after sham operation or TAC. E, Kaplan-Meier survival analysis of WT and KO mice in the presence of compound C or vehicle following TAC. Results are presented as mean ± SEM (n=10 to 15 per each group). *P<0.05 versus corresponding vehicle-treated mice and #P<0.05 versus corresponding WT mice.