Figure 6. Adenovirus mediated VEGF delivery reverses cardiac dysfunction in adiponectin deficient mice following pressure overload.
A, Representative images of CD31-stained heart sections from WT and KO mice treated with Ad-VEGF or Ad-βgal at 3 weeks after TAC in. Brown indicates CD31-positive endothelial cells, whereas light purple indicates nuclei in the hematoxylin stain. Magnification, ×400. B, Quantitative analysis of capillary density by measuring the number of CD31-positive cells per cardiomyocyte from each group. C, Echocardiographic analysis of the fractional shortening (FS) for WT and KO mice treated with Ad-VEGF or Ad-βgal at 3 weeks after TAC. Results are presented as mean ± SEM (n=4–7 per each group). *P<0.05 versus corresponding Ad-βgal treated mice and # P<0.05 versus corresponding WT mice.