Figure 10.
Proposed intervention points of JNK activation during acetaminophen (APAP)-induced liver injury.
Abbreviations: AIF, apoptosis-inducing factor; ASK, apoptosis signal-regulating kinase 1; GSH, glutathione; GSSG, glutathione disulfide; GST-Pi, glutathione S-transferase Pi; JNK, c-jun-N-terminal kinase; MOMP, mitochondrial outer membrane permeabilization; MPT, mitochondrial membrane permeability transition pore; NAPQI, N-acetyl-p-benzoquinone imine; NT adducts, nitrotyrosine adducts;