Figure 7.
Nitrotyrosine staining as indicator of peroxynitrite formation in mice treated with 600 mg/kg APAP for 6 h or 12 h. Some of the animals received PBS, DMSO or the JNK inhibitor SP600125 at 1 h before APAP administration. One group of animals was treated with the iNOS inhibitor L-N-(1-iminoethyl)lysine (L-NIL; 3.3 mg/kg) at 0 and 3 h after APAP.