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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2010 Apr 25;246(1-2):8–17. doi: 10.1016/j.taap.2010.04.015

Figure 9.

Figure 9

Hepatic content of total GSH (GSH + GSSG) (Panel A) and GSSG (Panel B) were measured in untreated controls (C) and in animals treated with 600 mg/kg APAP for 12 h. In addition, the GSSG-to-GSH ratio (Panel C) was calculated from each animal. Some of the animals received 15 ml/kg PBS (P), 15 ml/kg DMSO (8.3% in PBS) (D) or 10 mg/kg SP600125 in DMSO/PBS (SP) at 1 h before APAP administration. Data represent means ± SE of n = 4 animals per group. *P<0.05 (compared to C), #P<0.05 (compared to P).