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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Cell Death Differ. 2010 Jan 29;17(7):1189–1198. doi: 10.1038/cdd.2009.221

Figure 7. Hypothesized role of cell cycle activation in response to DNA damage in postmitotic neurons.

Figure 7

DNA damage generated by a genotoxic insult results in activation of the DNA damage response (DDR). Cell cycle reentry which is an essential element of the DDR, plays a role in both DNA repair and apoptosis. G1→S transition is critical for apoptotic signaling.