Figure 1. Schematic of the TOR signaling network.

TORC1 integrates intra- and extracellular environmental cues through discrete signaling modules that sense and relay diverse inputs to a central “signaling core” (in green). This figure summarizes biochemical evidence from various studies that have identified the inputs and outputs of TORC1. Various outputs (in grey) that keep cellular growth in balance with the environment are regulated by TORC1. See main text for details.